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Patients with Alzheimer's disease and anosognosia showed significant blood flow deficits in the frontal inferior and superior(dorsal)areas of the right hemisphere.On the other hand,no significant between-group differences were found in depression scores and neuropsychological tasks that assessed verbal and visual memory,verbal comprehension,naming,verbal fluency,auditory attention,abstract reasoning,and set-shifting abilities. Our study demonstrates that anosognosia may not be related to deficits in specific cognitive domains,but it may result from dysfunction of the right frontal lobe. |
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